The heads of the world’s two biggest economies will hold the bilateral at Mr Trump’s Mar-a-Lago retreat in Florida.
The American leader is expected to press his counterpart for action on North Korea, and Mr Xi to seek assurances on Taiwan.
Mr Trump tweeted last week that the summit “will be a very difficult one”.
Mr Xi and his wife, folk singer Peng Liyuan, will be treated to a welcome banquet on Thursday afternoon at Mr Trump’s palatial Palm
Beach resort with the US president and first lady, Melania Trump.
The bilateral will conclude with a working lunch on Friday.